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Most Americans don’t eat the recommended amounts of fruits and vegetables, says a U.S. government study released Tuesday. And no state has achieved national objectives for consumption of fruits and vegetables, it found.

The goal for the Healthy People 2010 program is to get at least 75 percent of Americans to eat the recommended two or more daily servings of fruit and for at least 50 percent of Americans to consume three or more daily servings of vegetables.

But surveys from the U.S. Centers for Disease Control and Prevention show that only 33 percent of adults meet the fruit consumption target and only 27 percent eat the recommended amount of vegetables. The statistics are worse for high school students — only 32 percent eat the recommended amount of fruit and 13 percent meet the goal for vegetables.

“A diet high in fruits and vegetables is important for optimal child growth, maintaining a healthy weight, and prevention of chronic diseases such as diabetes, heart disease and some cancers, all of which currently contribute to health care costs in the United States,” Dr. William H. Dietz, director of the CDC’s Division of Nutrition, Physical Activity and Obesity, said in a CDC news release.

“This report will help states determine what is taking place in their communities and schools and come up with ways to encourage people to eat more fruits and vegetables,” Dietz said.

The report — the State Indicator Report on Fruits and Vegetables, 2009 — is the first to detail state-by-state data about fruit and vegetable consumption and policies that may help boost fruit and vegetable consumption.

It spotlights three important policy and environmental areas associated with fruit and vegetable consumption: healthier food retail, availability of healthier foods in schools, and food system support.

Food stores that stock a variety of high-quality fruits and vegetables can play a key role in residents’ health, the report notes. But only eight states have a policy for healthier food retail improvements that can increase the number of full-service grocery stores in areas where they’re lacking, increase the availability of healthier foods in small food stores, and promote healthier foods by providing information to consumers in food stores.

Schools can influence better eating by students, staff, parents and other members of the community. But the report found that only 21 percent of U.S. middle schools and high schools offer fruits and non-fried vegetables in vending machines, school stores or snack bars. Fewer than half the states (21) have policies to support farm-to-school programs that can increase access to fruits and vegetables and teach students about nutrition and agriculture.

The report also mentioned food policy councils, which are organizations that look at access to fresh produce at the community and state levels. Food policy councils make recommendations about policies and programs such as community gardens, farmers’ markets, availability of fresh produce in supermarkets and farm-to-school programs. Currently, 59 local food policy councils operate across the United States, and 20 states have a state-level food policy council.

“We have seen the tremendous benefit of state and local officials, health professionals, employers, food store owners, farmers, school staff, and community members working together on food and nutrition issues,” CDC epidemiologist Heidi Michels Blanck said in the news release. “Their efforts can help to increase the availability of affordable healthier food choices such as fruits and vegetables.”

One in seven preschoolers from low-income families in the United States are considered obese, a new government report shows.

However, the same report finds that the news is not all bad: The childhood obesity epidemic does seem to be leveling off among children in this group.

Among 2- to 4-year-olds from low-income families, the prevalence of obesity increased from 12.4 percent in 1998 to 14.5 percent in 2003. However, it went up only to 14.6 percent in 2008, according to the July 24 issue of the Morbidity and Mortality Weekly Report, a publication of the U.S. Centers for Disease Control and Prevention.

“Among lower-income, preschool-aged children, we are actually seeing a stabilization of obesity rates,” said report co-author Laurence M. Grummer-Strawn, chief of CDC’s Maternal Child Nutrition Branch in the Division of Nutrition and Physical Activity.

“For a number of years, we were seeing continuous rises in this obesity epidemic and it looks like over the last five years we have actually seen that rate stabilize,” he said. “Of course, we are not where we want to be. We want to see much more improvement, but it’s at least good news that things are not continuing to get worse.”

Why obesity in this age group is stabilizing is not completely clear, Grummer-Strawn said. “There has been more emphasis on pediatric obesity among low-income populations,” he said. “There have been initiatives to promote breast-feeding, initiatives to use low-fat or skim milk, initiatives to reduce television watching and shaping behaviors toward better nutrition and physical activity,” he noted.

But there remains a large racial and ethnic disparity in the obesity epidemic among preschoolers, Grummer-Strawn added.

Even though the prevalence of obesity has stayed steady in many parts of the country, it is still increasing among American Indian and Alaska Native children. Among these children, the prevalence of obesity has gone up about a half-percentage point each year from 2003 to 2008, according to the report.

As a matter of fact, American Indian or Alaska Native children had the highest obesity rates in 2008, at 21.2 percent, followed by Hispanic children at 18.5 percent.

The lowest obesity rates were among white children, at 12.6 percent, Asian or Pacific Islander children, at 12.3 percent, and black children, at 11.8 percent, the report found.

Only in Colorado and Hawaii were the obesity rates 10 percent or less among poor preschoolers, and only among Indian Tribal Organizations were the obesity rates over 20 percent.

“We need to be thinking about how to change our communities to be much healthier for our children,” Grummer-Strawn said.

There need to be better parks and playgrounds “so that children can get outside and play,” he said. “We also need to improve access to healthier foods.”

The drug vorinostat is able to cross the blood-brain barrier and reduce the development of large metastatic tumors in mice brains by 62 percent when compared to mice that did not receive the drug, according to a new study. In humans, the drug has been approved by the U.S. Food and Drug Administration for the treatment of a cancer called cutaneous T-cell lymphoma but can be used experimentally to study its effectiveness against other cancers. This research, by investigators at the National Cancer Institute (NCI), part of the National Institutes of Health, and their collaborators, appears online Sept. 29, 2009, in Clinical Cancer Research.

For people, while various therapies are improving the survival of breast cancer patients, the incidence of breast cancer spreading to the brain is increasing. Brain metastases of breast cancer have proven to be largely untreatable because the blood-brain barrier, which arises from the specialized structure of blood capillaries in the brain, severely limits drug access and many drugs are actively transported out of brain at this barrier. Consequently, the one-year survival estimate for breast cancer patients after a diagnosis of brain metastasis is only about 20 percent.

Vorinostat has been found to slow the growth of primary tumors of several different types of cancer in mice. Previous studies have suggested that the drug can be taken up by the brain, although little was known about its effects on metastatic tumors. Therefore, to study the effect of vorinostat on the formation of brain metastases, scientists used a mouse model of human breast cancer. Human breast cells were cultured in the laboratory and were injected into mice with compromised immune systems. The breast cancer cells then migrated to the brain, forming metastases.

“Drugs that can cross the blood-brain barrier and reduce the size and incidence of metastatic tumors are urgently needed,” said Patricia S. Steeg, Ph.D., study author, Center for Cancer Research, NCI. The researchers found that vorinostat was absorbed readily into normal mouse brains, and accumulation of the drug was up to three-fold higher in some metastases treated with this drug when compared to surrounding brain tissue. Vorinostat also reduced the development of tiny tumors (micrometastases) in mice by 28 percent when compared with mice that did not receive this therapy.

The ability of vorinostat to reduce metastatic lesions in the brain was linked to a novel double-barreled mechanism — the drug can cause breaks in both strands of a DNA helix and can also lower the activity of a DNA repair gene called Rad52. The researchers hypothesize that the inability of the cancer cells to repair DNA damage would then slow the rate of tumor cell metastasis.

In June of this year, several researchers affiliated with this study published a paper in Molecular Cancer Therapeutics showing that vorinostat could enhance the effect of radiation therapy in mice with brain cancer metastasis. Mice that received implants of human breast tumors in their brains lived the longest after treatment with both vorinostat and radiation, demonstrating that the drug enhances the sensitivity of cancer cells to radiation therapy. “Taken together with our current finding, researchers have now established a preclinical basis for testing this drug in clinical trials in humans,” said Steeg.